Tadarise typically starts working 30 to 60 minutes after you take it. It contains tadalafil, a PDE5 inhibitor that increases blood flow to the penis, helping to achieve and maintain an erection when sexually stimulated. The onset time can vary slightly based on factors like your metabolism, diet, and overall health. For best results, Tadarise should be taken on an empty stomach or after a light meal. Taking it with a heavy or high-fat meal may delay the absorption of the drug and slow down its effectiveness. A full glass of water is recommended when taking the tablet. Unlike some other ED medications, Tadarise offers a long window of effectiveness.